7 JCI-accredited hospitals 17 hospitals with oncology 65 oncology specialists 19 clinical trials recruiting
Oncology & Cancer Care
Clinical trials at Acıbadem

Find a clinical trial

Every study below is registered on ClinicalTrials.gov and has an Acıbadem hospital in Turkey as a site. Search by cancer, status or phase. If you are not sure whether a study fits, send your reports: the study team checks eligibility for you at no cost.

  • 19recruiting now
  • 40studies listed
  • 25sponsors
  • 24 Sep 2026last updated
Browse by group
MechanismAntibody · checkpoint blockadeAn engineered antibody locks onto the tumour cell's PD-L1 shield so T cells can attack.

Recruiting Phase 3 NCT05920356 A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202) Non-Small Cell Lung Cancer (NSCLC) Sotorasib, Pembrolizumab Istanbul Amgen Recruiting Phase 3 NCT06492616 A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence Breast Cancer Elacestrant, Anastrozole, Letrozole, Exemestane, Tamoxifen Istanbul Stemline Therapeutics, Inc. Recruiting Phase 3 NCT05254743 A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) Chronic Lymphocytic Leukemia · Leukemia, Lymphocytic · Leukemia, B-cell Pirtobrutinib, Ibrutinib Istanbul Loxo Oncology, Inc. Recruiting Phase 3 NCT07174336 A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA) Breast Neoplasms · Neoplasm Metastasis LY4064809, Placebo, Ribociclib, Palbociclib, Abemaciclib, Anastrozole,… Istanbul Eli Lilly and… Recruiting Phase 3 NCT04928846 A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Non Small Cell Lung Cancer Telisotuzumab Vedotin, Docetaxel Adana AbbVie Recruiting Phase 3 NCT05020236 A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments Multiple Myeloma Elranatamab, Daratumumab, Pomalidomide, Dexamethasone Istanbul Pfizer Recruiting Phase 2/Phase 3 NCT01949129 Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia Acute Lymphoblastic Leukaemia VP16, TBI, Thiotepa, Treosulfan, Fludarabine, Busulfan,… Istanbul St. Anna Kinderkrebsforschung Recruiting Interventional NCT07345221 Effect of Hilotherapy in the Management of Symptoms Related to Taxane-Associated Peripheral Neuropathy Peripheric Neuropathy Hilotherapy Istanbul Nuran Ayşen Pamir… Recruiting Phase 3 NCT03486873 Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) Solid Tumors · Hematologic Malignancies Pembrolizumab, Standard of Care (SOC), Lenvatinib,… Üsküdar /Istanbul, Adana, Istanbul Merck Sharp &… Recruiting Observational NCT06071507 Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy Gastric Outlet Obstruction · Pancreatic Cancer Istanbul IRCCS San Raffaele Recruiting Observational NCT07345247 RAdiation SEgmentectomy With REsin Microspheres (RASEREM) Study Liver Cancer, Adult Adana, Izmir Ankara University Recruiting Phase 2/Phase 3 NCT07413939 RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive HER2-positive Breast Cancer RO7771950, Tucatinib, Trastuzumab, Capecitabine Izmir Hoffmann-La Roche Recruiting Phase 3 NCT06712355 Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer Extensive-stage Small-cell Lung Cancer Pumitamig, Atezolizumab, Etoposide, Carboplatin (or cisplatin… Adana BioNTech SE Recruiting Phase 2/Phase 3 NCT06712316 Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer Non-small Cell Lung Cancer Pumitamig, Pembrolizumab, Carboplatin, Pemetrexed, Paclitaxel Seyhan BioNTech SE Recruiting Phase 1/Phase 2 NCT05386108 Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer Breast Neoplasms · Brain Neoplasms · Central Nervous System Neoplasms Elacestrant, Abemaciclib Istanbul Stemline Therapeutics, Inc. Recruiting Observational NCT07168616 Study of PSMA PET/CT Imaging to Help Select Men With Low-Risk Prostate Cancer for Active Surveillance Low Risk Prostate Cancer · Clinically Significant Prostate Cancer Ga-68 PSMA11 PET/CT Istanbul Istanbul University -… Recruiting Phase 3 NCT06252649 Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation Metastatic Colorectal Cancer FOLFIRI Regimen, Sotorasib, Panitumumab, Bevacizumab-awwb Istanbul Amgen Recruiting Phase 3 NCT07222566 Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Advanced Non-Small Cell Lung Cancer · Non-Small Cell Lung Cancer · Carcinoma, Non-Small-Cell Lung PF-08634404, Pembrolizumab, Chemotherapy Regimen 1, Chemotherapy… Üsküdar / İstanbul Pfizer Recruiting Phase 3 NCT06520345 The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global) Metastatic Castration-resistant Prostate Cancer 177Lu-TLX591, Enzalutamide, Abiraterone, Docetaxel Istanbul Telix Pharmaceuticals (Innovations)… Opening soon Observational NCT06823297 Can Neoadjuvant Chemoradiotherapy be Ommited in Mid-rectal Cancer Mid-Rectal Cancer · Rectal Cancer Stage II · Rectal Cancer Stage III Total mesorectal excision, Neoadjuvant Chemotherapy followed… Izmir Turkish Society of… Opening soon Observational NCT06902701 Endoscopic Submucosal Dissection vs. Transanal Endoscopic Surgery for Rectal Neoplasia Rectal Neoplasms Endoscopic Submucosal Dissection (ESD), Transanal Endoscopic… Izmir Turkish Society of… Opening soon Phase 3 NCT07476729 International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 (IntReALL BCP 2020) B-Cell Acute Lymphoblastic Leukaemia Inotuzumab ozogamicin (INO), Blinatumomab Istanbul Charite University, Berlin,… By invitation Observational NCT07289568 Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study) Colon Cancer · Splenic Flexure Mobilization · Right Hemicolectomy Colectomy Istanbul Acibadem University Active, closed to enrolment Phase 3 NCT05933577 A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001) Melanoma Intismeran autogene, Pembrolizumab, Placebo Istanbul Merck Sharp &… Active, closed to enrolment Phase 3 NCT04680052 A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma. Follicular Lymphoma · Marginal Zone Lymphoma tafasitamab, rituximab, lenalidomide, placebo Istanbul Incyte Corporation Active, closed to enrolment Phase 3 NCT04961996 A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician’s Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer) Early Breast Cancer Giredestrant, Physician's Choice of Endocrine Therapy,… Üsküdar Hoffmann-La Roche Active, closed to enrolment Phase 3 NCT04712097 A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma Relapsed or Refractory Follicular Lymphoma Mosunetuzumab, Lenalidomide, Rituximab, Tociluzumab Istanbul Hoffmann-La Roche Active, closed to enrolment Phase 3 NCT04770896 A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab Unresectable Hepatocellular Carcinoma Atezolizumab, Lenvatinib, Sorafenib Istanbul Hoffmann-La Roche Active, closed to enrolment Phase 1/Phase 2 NCT03473743 A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer Urothelial Carcinoma Erdafitinib, Cetrelimab, Cisplatin, Carboplatin Adana Janssen Research &… Active, closed to enrolment Phase 3 NCT04975308 A Study of Imlunestrant, Investigator’s Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer Breast Neoplasms · Neoplasm Metastasis Imlunestrant, Exemestane, Fulvestrant, Abemaciclib Üsküdar / Stanbul, Istanbul Eli Lilly and… Active, closed to enrolment Phase 3 NCT05388669 A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer Advanced or Metastatic Non-small Cell Lung Cancer Lazertinib, Amivantamab Subcutaneous and Co-Formulated with… Istanbul Janssen Research &… Active, closed to enrolment Phase 3 NCT04194944 A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer Selpercatinib, Carboplatin, Cisplatin, Pemetrexed, Pembrolizumab Sariyer Eli Lilly and… Active, closed to enrolment Phase 3 NCT05152147 A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers Gastric Neoplasms · Gastroesophageal Adenocarcinoma · Esophageal Adenocarcinoma Zanidatamab, Tislelizumab, Trastuzumab, Capecitabine, Oxaliplatin, Cisplatin,… Seyhan Jazz Pharmaceuticals Active, closed to enrolment Phase 3 NCT03155997 Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer Breast Cancer Abemaciclib, Standard Adjuvant Endocrine Therapy Üsküdar/stanbul Eli Lilly and… Active, closed to enrolment Phase 3 NCT05611931 Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma Endometrial Cancer Selinexor, Matching Placebo for selinexor Istanbul Karyopharm Therapeutics Inc Active, closed to enrolment Phase 3 NCT05382286 Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician’s Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer Triple Negative Breast Cancer · PD-L1 Positive Sacituzumab Govitecan-hziy, Pembrolizumab, Paclitaxel, nab-Paclitaxel, Gemcitabine,… Sariyer Gilead Sciences Completed Phase 3 NCT03523585 DS-8201a in Pre-treated HER2 Breast Cancer That Cannot be Surgically Removed or Has Spread [DESTINY-Breast02] Breast Cancer Trastuzumab deruxtecan, Capecitabine, Lapatinib, Trastuzumab Adana Daiichi Sankyo Completed Phase 3 NCT01265849 Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity Squamous Cell Carcinoma of the Oral Cavity · Squamous Cell Carcinoma of the Soft Palate LI, Cyclophosphamide, Indomethacin, Zinc, Surgery, Cisplatin,… Istanbul CEL-SCI Corporation Completed Phase 3 NCT03740165 Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036) Ovarian Cancer · Fallopian Tube Cancer · Peritoneal Neoplasms Pembrolizumab, Placebo for pembrolizumab, Carboplatin, Paclitaxel,… Küçükçekmece Merck Sharp &… Completed Phase 3 NCT03834493 Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641) Prostatic Neoplasms Pembrolizumab, Enzalutamide, Placebo Istanbul Merck Sharp &…
How trials work

What a clinical trial is, and what it is not

A clinical trial is how a new treatment earns its place in standard care. Most of the drugs used today in oncology were tested in trials like the ones listed here.

IIs it safe?

A small group receives the treatment first. The team finds the right dose and watches for side effects.

IIDoes it work?

A larger group with one cancer type. Researchers measure tumour response and keep monitoring safety.

IIIIs it better?

Hundreds to thousands of patients in many countries, compared with the current standard. Most Acıbadem studies are Phase 3.

IVAfter approval

Long-term benefits and rare side effects are tracked in everyday care.

No placebo instead of treatment

In cancer trials a placebo is only ever added on top of the best available standard treatment, and you are told in advance.

Closer follow-up than usual

Trial patients are seen more often, with more scans and blood tests, by a dedicated study nurse and physician.

Open to international patients

Eligibility depends on diagnosis and health, not nationality. Coordinators help with visa, stay and translated consent forms.

Second opinion · Free case review

Send your reports and get a plan from a tumour board, not a single doctor

Pathology, imaging and previous treatment history are enough to start. Written recommendation within 48 hours, including trial eligibility.